The development of strategies and methods for the synthesis of biologically active compounds

This review describes new strategies and methodology for asymmetric and stereoselective syntheses that have been developed within the Nelson group at the University of Leeds, UK. Syntheses of C-substituted monosaccharides, C-linked disaccharide mimetics, the C58–C71 fragment of palytoxin and an established intermediate in a total synthesis of Hemibrevetoxin B are described. The work is described within the context of related research in organic chemistry.