Key result
Two new types of bipolar cuff microelectrodes using electro-conductive rubber or water-absorbent polymer successfully recorded renal sympathetic nerve activity in anesthetized rats.
Novel implantable microelectrodes using electro-conductive rubber or water-absorbent polymer allow for effective recording of sympathetic nerve activity in small animals.
Enables refined sympathetic recordings in rat models; leaves open validation for chronic or translational use.
We have developed two new types of bipolar cuff microelectrodes (volume size, 2-3 mm(3)) using electro-conductive rubber or water-absorbent polymer, either of which can be applied to measure sympathetic nerve activity in small animals. A renal nerve bundle of an anesthetized rat was inserted into the center hole of the electrode (diameter, 0.15 mm) through a slit and had good contact with the electrodes. Renal sympathetic nerve activity, which was verified by sympathetic ganglionic blockade, could be recorded using either type of implantable cuff electrode.
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Matsukawa et al. (2003) studied this question. Bipolar cuff microelectrodes (electro-conductive rubber or water-absorbent polymer) was evaluated on Recording of renal sympathetic nerve activity (RSNA). Two new types of bipolar cuff microelectrodes using electro-conductive rubber or water-absorbent polymer successfully recorded renal sympathetic nerve activity in anesthetized rats.
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