Key result
Acute hydration with isotonic saline reduced postural reductions in mean blood pressure from 40 mmHg to 20 mmHg (P<0.01) in patients with autonomic failure.
Why the study?
Does acute hydration with isotonic saline improve blood pressure in patients with severe postural hypotension due to autonomic failure?
Does acute hydration with isotonic saline improve blood pressure in patients with severe postural hypotension due to autonomic failure?
Absolute Event Rate: 20% vs 40%
p-value: p=<0.01
Acute hydration with isotonic saline significantly improves supine blood pressure and reduces postural hypotension in patients with autonomic failure, despite normal baseline plasma volumes.
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May support acute hydration for orthostatic hypotension in autonomic failure; case-report data leave confirmation to prospective trials.
Mehlsen et al. (1987) studied Severe postural hypotension due to autonomic failure (n=10). Acute hydration with isotonic saline vs. Baseline (before saline infusion) was evaluated on Postural reductions in mean blood pressure (p=<0.01). Acute hydration with isotonic saline reduced postural reductions in mean blood pressure from 40 mmHg to 20 mmHg (P<0.01) in patients with autonomic failure.
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