Medizinisch interessante Metallchelate, I. 99mTc‐Komplexe mit sechszähnigen Tribrenzkatechin‐Liganden

Metal Chelates of Medical Interest, I. – 99mTc Complexes with Hexadentate Tricatechol Ligands The tricatechol ligand tris[3‐(2,3‐dihydroxyphenoxy)propyl]‐amine hydrochloride, TRIPACE (9), is prepared from tris(3‐chlorpropyl)amine (5) and the potassium salt of 2,2‐dimethyl‐1,3‐benzodioxol‐4‐ol (7). This ligand is capable of reducing the 99m[TcO4]− ion to lower valent 99mTc and subsequent complexation of the reduced 99mTc ion. The structures of 5 and of tris[3‐(2,2‐dimethyl‐1,3‐benzodioxol‐4‐yloxy)propyl]amine (8) are determined by X‐ray diffraction.