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Familial atrial fibrillation occurred in 21 of 49 members across three families from northern Spain, diagnosed at young ages (2 to 46 years) without identifiable secondary causes.
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This editorial highlights the potential genetic basis of atrial fibrillation in families presenting without traditional risk factors.
In their article in this issue of the Journal, Brugada and coworkers1 describe three families, all from the same region in northern Spain, in which 21 of 49 family members had atrial fibrillation. Two died of cerebrovascular accidents at 36 and 68 years of age. Of the 19 living family members, 18 had chronic atrial fibrillation, whereas 1 had paroxysmal atrial fibrillation. In none of these patients could a specific cause of atrial fibrillation, such as hypertension, valvular disease, or hyperthyroidism, be found. The age at diagnosis ranged from 2 to 46 years in the three families. Comparison of pooled . . .
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Maurits A. Allessie (1997) conducted an editorial in Atrial fibrillation (n=49). Familial inheritance was evaluated on Atrial fibrillation. Familial atrial fibrillation occurred in 21 of 49 members across three families from northern Spain, diagnosed at young ages (2 to 46 years) without identifiable secondary causes.
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