Key result
This review summarizes the molecular mechanisms and signaling pathways involved in myotonic dystrophy type 1 muscle dysfunction to identify potential new therapeutic targets.
Why the study?
DM1 is the most prevalent adult muscular dystrophy lacking treatments, and knowledge regarding its affected signalling cascades and pathways beyond RNA toxicity remains dispersed.
Design
Review
Authors
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No immediate change to DM1 care; leaves open which summarized pathways merit clinical validation.
This review organizes current knowledge on the diverse molecular pathways affected in myotonic dystrophy type 1 to highlight potential new therapeutic targets.
Ozimski et al. (2020) conducted a review in Myotonic dystrophy type 1 (DM1). This review summarizes the molecular mechanisms and signaling pathways involved in myotonic dystrophy type 1 muscle dysfunction to identify potential new therapeutic targets.
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