Key result
Low ankle brachial index was associated with a significantly lower median left ventricular ejection fraction compared to normal ABI (33% vs. 61%, p=0.001) in patients without coronary artery disease.
Why the study?
Is ankle brachial index associated with left ventricular ejection fraction in patients without coronary artery disease?
Observational (n=55)
Is ankle brachial index associated with left ventricular ejection fraction in patients without coronary artery disease?
Ankle brachial index is independently associated with left ventricular ejection fraction in patients without coronary artery disease, suggesting LVEF may influence ABI independently of CAD or arterial stiffness.
Low ABI may indicate reduced LVEF without CAD; hypothesis-generating and should not yet change practice.
BACKGROUND: The low ankle brachial index (ABI) values are indicative of peripheral arterial disease, but have recently been found to be associated with reduced left ventricular ejection fraction (LVEF). This may relate to coexisting coronary artery disease (CAD). AIM: This study prospectively assessed a potential ABI-LVEF association in patients without CAD. METHODS AND RESULTS: We studied 55 patients (age 57 ± 13 years, 49% male) with normal coronary arteries with LVEF determination. ABI, pulse wave velocity (PWV), and augmentation index (AI) were performed after coronary angiography. ABI correlated with LVEF (r = 0.40, p = 0.002), but not with PWV or AI. On linear regression analysis, ABI was independently associated with LVEF (B = 0.42, p = 0.004). The median LVEF was lower in subjects with low ABI values compared to those with normal ABI values (33 vs. 61%; p = 0.001). CONCLUSION: ABI may be influenced by LVEF independently of CAD, arterial stiffness or pressure wave reflection.
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Nunez et al. (2018) conducted an observational in Patients without coronary artery disease (n=55). Low ankle brachial index (ABI) vs. Normal ABI values was evaluated on Left ventricular ejection fraction (LVEF) (p=0.001). Low ankle brachial index was associated with a significantly lower median left ventricular ejection fraction compared to normal ABI (33% vs. 61%, p=0.001) in patients without coronary artery disease.
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