Synthesis of the possible analgesic and/or antiinflammatory agent 5-benzoyl-6-trifluoromethyl-1,2-dihydro-3H-pyrrolo[1,2-α]pyrrole-1-carboxylic acid (1) was designed from the already known intermediate ester 3-methoxycarbonyl-4-trifluoromethyl-5-benzyloxycarbonylpyrrole-2-acetic acid methyl ester (4) wich is prepared via a Knorr synthesis.
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Adrián Covarrubias Zúñiga (2004) studied this question.
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