Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs

Weisberg et al[1][1] recently demonstrated additive or synergistic effects when nilotinib was combined with imatinib in BCR-ABL+ leukemic cell lines. The authors speculated that this synergy might be due to interactions with drug transporters. Recent studies in our laboratory using 14C-labeled