From Aziridines to Oxazolines and Thiazolines: The Heterocyclic Route to Thiangazole

All articles of this category Since its isolation in 1991, the polyazole natural product thiangazole has become a popular target for total synthesis due to its challenging array of heterocyclic segments and its reported potent antiviral activity. The synthetic activity toward thiangazole is reviewed and a novel approach that takes advantage or aziridine and oxazoline intermediates en route to thiazolines is presented. Staudinger reaction - α-methyl serine - α-methyl cysteine - thiolysis - Burgess reagent