Key result
High dose intravenous contrast agents and an osmotically similar solution caused a reproducible decrease in renal blood flow and glomerular filtration rate.
Why the study?
Do high dose intravenous contrast agents affect renal blood flow and glomerular filtration rate compared to an osmotically similar solution?
Do high dose intravenous contrast agents affect renal blood flow and glomerular filtration rate compared to an osmotically similar solution?
High dose intravenous contrast agents and osmotically similar solutions both cause a reproducible decrease in renal blood flow and glomerular filtration rate, suggesting an osmotic mechanism for contrast-induced renal changes.
Supports osmotic mechanism in this animal model; leaves open translation to human contrast nephropathy.
Because of renewed interest in renal insufficiency after excretory urography a set of experiments was designed to determine the effects of high dose intravenous contrast agents on renal blood flow and glomerular filtration rate. A reproducible decrease in renal blood flow and glomerular filtration rate was noted with high dose intravenous contrast agents and an osmotically similar solution without the radiographically active compound. The results are discussed in light of clinical significance.
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Forrest et al. (1981) studied Renal function. High dose intravenous contrast agents vs. Osmotically similar solution without the radiographically active compound was evaluated on Renal blood flow and glomerular filtration rate. High dose intravenous contrast agents and an osmotically similar solution caused a reproducible decrease in renal blood flow and glomerular filtration rate.
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