Applying Proteomics to Study Crosstalk at the Cartilage-Subchondral Bone Interface in Osteoarthritis: Current Status and Future Directions

Osteoarthritis (OA) is the most common age-related degenerative joint disorder. It is considered a disease of the entire joint, which is not simply a result of attrition but rather abnormal remodelling and coalescent failure of multiple tissues. Despite the prevalence of OA, therapeutic strategies are currently limited to the treatment of pain and inflammation. New disease-modifying agents that slow progression and diagnostic biomarkers are urgently required. Given the lack of treatment options to repair degradation of articular cartilage, anti-resorptive agents and anabolics, such as bisphosphonates, are candidate treatments for OA (Karsdal et al., 2014).