Why the study?
Do beta-adrenergic-antagonists prevent initial episodes of gastrointestinal bleeding in patients with cirrhosis and esophageal varices?
Meta-Analysis (n=589)
Yes
Do beta-adrenergic-antagonists prevent initial episodes of gastrointestinal bleeding in patients with cirrhosis and esophageal varices?
Prophylactic beta-blocker therapy with propranolol or nadolol significantly reduces the risk of first gastrointestinal bleeding and fatal bleeding in patients with cirrhosis and esophageal varices.
Supports beta-blocker prophylaxis to prevent first variceal bleed in cirrhosis; confirms efficacy in Level 1 meta-analysis.
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Gumucio et al. (1992) conducted a meta-analysis in Cirrhosis and esophageal varices (n=589). Beta-adrenergic-antagonist therapy (propranolol or nadolol) vs. Placebo was evaluated on No upper gastrointestinal bleeding (p=0.002).
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