Key result
Vagal nerve stimulation at 50 Hz for 2 s or 2 Hz for 10 s revealed A, B, and C fiber thresholds that correlated with respiratory and heart rate changes in anesthetized rats.
A simple in vivo protocol using specific stimulation parameters can define thresholds for vagal A, B, and C fibers that correlate with physiological responses like heart rate.
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May guide fiber-specific vagal parameters in animal models; leaves open translation to human cardiovascular neuromodulation.
Vagal nerve stimulation is widely used therapeutically but the fiber groups activated are often unknown. AIM: To establish a simple protocol to define stimulus thresholds for vagal A, B and C fibers. METHODS: The intact left or right cervical vagus was stimulated with 0.1 ms pulses in spontaneously breathing anesthetized rats. Heart and respiratory rate responses to vagal stimulation were recorded. The vagus was subsequently cut distally, and mass action potentials to the same stimuli were recorded. RESULTS: Stimulating at either 50 Hz for 2 s or 2 Hz for 10 s at experimentally determined strengths revealed A, B and C fiber thresholds that were related to respiratory and heart rate changes. CONCLUSION: .
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McAllen et al. (2017) studied this question. Vagal nerve stimulation was evaluated on A, B and C fiber thresholds related to respiratory and heart rate changes. Vagal nerve stimulation at 50 Hz for 2 s or 2 Hz for 10 s revealed A, B, and C fiber thresholds that correlated with respiratory and heart rate changes in anesthetized rats.
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