Key result
A higher genetic predisposition score was associated with greater reductions in glycemia (p=0.048), triglycerides (p=0.002), and total cholesterol (p=0.038) 1 year after Roux-en-Y gastric bypass.
Why the study?
Does a higher Genetic Predisposition Score predict better metabolic outcomes in obese patients 1 year after Roux-en-Y gastric bypass?
Cohort (n=150)
Does a higher Genetic Predisposition Score predict better metabolic outcomes in obese patients 1 year after Roux-en-Y gastric bypass?
A higher genetic predisposition score based on 7 obesity-related polymorphisms is associated with greater improvements in glycemia and lipid profiles 1 year after Roux-en-Y gastric bypass.
Should not yet change RYGB candidate selection; leaves open whether genetic scores predict metabolic response in prospective cohorts.
BACKGROUND/AIMS: Genetic variants associated with obesity have cumulative effects on obesity risk and related phenotypes. This study aimed to estimate the contribution of a genetic predisposition score (GPS) calculated from 7 obesity-related polymorphisms to the improvement of biochemical parameters 1 year after Roux-en-Y gastric bypass (RYGB). METHODS: Obese patients (n = 150; aged 47.2 ± 10.5 years) were enrolled and weight, body mass index (BMI), and biochemical parameters (glycemia and lipid profile) were evaluated preoperatively and 1 year after RYGB. A GPS was calculated with the polymorphisms rs1801282 of PPARG2, rs4994 of ADRB3, rs1800592 of UCP1, rs659366 and rs669339 of UCP2, rs7121 of GNAS1, and rs5443 of GNB3. We observed that 66.3% of the patients has a GPS >5. RESULTS: During the preoperative period, the GPS showed a significant association with weight (β = -0.163; p = 0.020), BMI (β = -0.169; p = 0.038), and glucose concentrations (β = -0.177; p = 0.036). After sex and age adjustment, a higher GPS was associated with a greater reduction in glycemia (β = -0.158; p = 0.048), triglycerides (β = -0.256; p = 0.002), and total cholesterol (β = -0.172; p = 0.038) concentrations 1 year after surgery. CONCLUSION: Our data elucidated that a higher GPS provides a greater metabolic benefit of RYGB.
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Nicoletti et al. (2016) conducted a cohort in Obesity (n=150). Higher genetic predisposition score (GPS) from 7 obesity-related polymorphisms vs. Lower GPS was evaluated on Reduction in glycemia, triglycerides, and total cholesterol concentrations 1 year after surgery (β = -0.158 (glycemia), β = -0.256 (triglycerides), β = -0.172 (total cholesterol), p=0.048, 0.002, 0.038 respectively). A higher genetic predisposition score was associated with greater reductions in glycemia (p=0.048), triglycerides (p=0.002), and total cholesterol (p=0.038) 1 year after Roux-en-Y gastric bypass.
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