Key result
Total hemoglobin demonstrated a non-linear association with cognition in older adults, with inflection points of 15.10 g/dL for males and 11.72 g/dL for females.
Why the study?
The study aimed to identify the potential non-linear relationship between hemoglobin and cognition among cognitively normal older adults and examine how it differs by gender.
Cross-Sectional
Exploratory GAM findings of non-linear Hgb-cognition links by gender are hypothesis-generating; prospective studies needed before any clinical consideration.
Objectives: This exploratory study aimed to identify the potential non-linear relationship between hemoglobin (Hgb) and cognition among cognitively normal older adults and how this relationship differs in terms of gender in generalized additive models (GAM). Methods: This is a secondary data analysis using Wave II (2010–2011) data from the National Social Life, Health, and Aging Project. A generalized additive model was used to understand the non-linear relationship between Hgb and cognition, and to identify critical Hgb point related to cognition. Results: While both genders had a non-linear association between Hgb and cognition, the degree of non-linearity was more pronounced in male older adults with EDF value close to 2. The inflection point of 15.10 g/dL for male older adults and inflection point of 11.72 g/dL for female older adults were obtained. Conclusion: Further studies are needed to validate these results and develop precision medicine approaches to integrate these results into clinical practice.
No takes yet. Share an insight, caveat, or question.
Min et al. (2023) conducted a cross-sectional in Cognitively normal. Total Hemoglobin was evaluated on Cognition. Total hemoglobin demonstrated a non-linear association with cognition in older adults, with inflection points of 15.10 g/dL for males and 11.72 g/dL for females.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: