Key result
Continuous infusion of cis-platinum was linked to two episodes of supraventricular tachycardia in a patient with ovarian cancer, suggesting potential platinum-related cardiac toxicity.
This case report highlights a potential association between cis-platinum infusion and the development of supraventricular tachycardia.
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May warrant arrhythmia monitoring during cis-platinum; leaves open causal cardiotoxicity pending larger studies.
A 51-year-old woman with carcinoma of the ovary developed two episodes of supraventricular tachycardia during two consecutive cycles of combination chemotherapy. Both episodes occurred on day 5 of the 5-day continuous infusion schedule of cis-platinum. Underlying causes known to produce supraventricular tachycardia were ruled out. The possibility of platinum-related cardiac toxicity is discussed.
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Hashimi et al. (2009) studied this question. Continuous infusion of cis-platinum was linked to two episodes of supraventricular tachycardia in a patient with ovarian cancer, suggesting potential platinum-related cardiac toxicity.
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