The components from aerial parts of Sarcosperma affinis Gagnep. and their antibacterial activities

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Sixteen compounds were isolated from the aerial parts of Sarcosperma affinis Gagnep. including (E)-phytol (1), heptadecan-1-ol (2), lupeol (3), oleanolic acid (4), 3β-hexadecanoyloleanolic acid (5), pomolic acid (6), euscaphic acid (7), myrianthic acid (8), (+)-pinoresinol (9), (+)-medioresinol (10), (+)-syringaresinol (11), quercetin-3-O-β-D-galactopyranoside (12), epicatechin (13), bis-(2-ethylhexyl) phthalate (14), 3-prenyl-4-O-β-D-glucopyranosyloxy-4-hydroxylbenzoic acid (15), icariside E5 (16). Their structures were elucidated by the combination of spectroscopy including 1D, 2D NMR, HR-ESI-MS and in comparison with the reported NMR data in the literature. Among those, compounds 4 and 6 showed potent antibacterial activity against Mycobacterium smegmatis with MIC values of 5.48 and 2.65 μM, respectively. The chemical composition and biological activity of constituents isolated from aerial parts of S. affinis was studied for the first time.