Experimental study demonstrates transient sinoauricular block following local injections near the sinus node, suggesting mechanical reflex inhibition rather than pharmacological effects.
The subepicardial injection of 0.1 cc of digitalis or of a strophanthin preparation, as well as of other substances, over the sinus area leads to the immediate but transient appearance of sinoauricular block. This phenomenon is attributed to a reflex inhibition of the sinus node centers caused by the mechanical stimulus and not to a specific effect of the injected substances. In some instances the centers of the auriculo-ventricular node are also inhibited.
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David Scherf (1946) studied this question.
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