Key result
Purified f.VIII/vWf protein from a patient with von Willebrand's disease showed multiple biochemical and functional abnormalities compared to normal protein, including decreased vWf activity.
Population
Plasma from 1 patient with von Willebrand's disease with classic laboratory findings except for…
Comparison
Biochemical and functional characterization of… vs Purified normal f.VIII/vWf protein
Design
Other
Authors
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Single-patient vWD protein defects suggest structural contributors; leaves open generalizability and mechanistic roles pending larger studies.
Case Report (n=1)
This study identifies multiple biochemical and functional abnormalities in the f.VIII/vWf protein of a patient with von Willebrand's disease, including the absence of larger multimers and specific carbohydrate deficiencies.
Gralnick et al. (1982) conducted a case report in von Willebrand's disease (n=1). Purified f.VIII/vWf protein from vWd patient vs. Purified normal f.VIII/vWf protein was evaluated on Biochemical and functional abnormalities of f.VIII/vWf protein. Purified f.VIII/vWf protein from a patient with von Willebrand's disease showed multiple biochemical and functional abnormalities compared to normal protein, including decreased vWf activity.
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