SIMPLE 1H NMR observation of cooperative hydrogen bonding in O‐3′‐sucrose derivatives

Application of the SIMPLE NMR method (secondary isotope multiplet NMR of partially labelled entities) to O‐3′‐sucrose derivatives in DMSO‐d6 solution reveals the presence not only of the 1‐OH Fru…︁‐2‐OH Glu intramolecular hydrogen bond in 3,3′,4′,6′‐tetra‐O‐acety Isucrose, but also of an extensive hydrogen bond network in the glucose residue of 3′,6′‐di‐O‐benzoylsucrose, i.e. 2‐OH…︁3‐OH…︁4‐OH…︁6‐OH.