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The role of root canal sealers is to close cavities in the canal and open accessory canals and multiple holes, create a connection between the canal wall and the surface of the filling material, and act as plasticizers for core fillings. The sealers are grouped according to their main chemical components: seals based on zinc oxide eugenol, caoh,gic, silicone, resin and bioceramics bioactive materials such as glass and calcium phosphate combine with the surrounding tissue to stimulate the growth of more robust tissue. Bioinert materials like zirconia and alumina has no effects on the adjacent tissues.
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Chellapandian et al. (2022) studied this question.
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