Nickel‐catalyzed hydrogen isotope exchange

Nickel metal in various forms is useful for the catalytic exchange labeling of a wide range of compounds from isotopic water or isotopic hydrogen gas sources. Substantial investigative work has been done on the metal's activities in simple test compounds, providing information useful for selecting or developing conditions for labeling of more complex substances. In addition, Raney nickel has been shown to be particularly useful for labeling of carbohydrates, for which the assembled empirical data are sufficient for limited predictive purposes in new glycosides.