Key result
In rat hippocampal neurones, BK channels exhibited Ca2+-dependent inactivation requiring at least 1 microM intracellular Ca2+, switching to a low open probability state (mean Po 0.001).
Population
Acutely dissociated rat hippocampal CA1 neurones
Design
Preclinical
Authors
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BK inactivation in rat hippocampal neurons warrants caution extrapolating to humans; leaves open its role in human excitability or disease.
Hippocampal BK channels undergo Ca2+-dependent inactivation, likely resulting from pore block by an associated intracellular particle.
Hicks et al. (1998) studied this question. Intracellular Ca2+ was evaluated on Channel inactivation (open probability). In rat hippocampal neurones, BK channels exhibited Ca2+-dependent inactivation requiring at least 1 microM intracellular Ca2+, switching to a low open probability state (mean Po 0.001).
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