Polyester/cellulose acetate composites: Preparation, characterization and biocompatible

The biocompatibility, morphology, and mechanical thermal properties of composite materials composed of maleic anhydride‐grafted polylactide (PLA‐g‐MA) and cellulose acetate (CA) were evaluated. Composites containing maleic anhydride‐grafted PLA (PLA‐g‐MA/CA) exhibited noticeably superior mechanical properties due to greater compatibility between the two components. The dispersion of CA in the PLA‐g‐MA matrix was highly homogeneous as a result of ester formation, and the consequent creation of branched and cross‐linked macromolecules, between the carboxyl groups of PLA‐g‐MA and hydroxyl groups in CA. The human skin dermal fibroblasts (FBs) seeded on these two novel series membranes to verify the wound dressing characterization properties. With time‐dependent course, the FBs proliferation demonstrated a better increasing performance on the series membranes of PLA/CA than PLA‐g‐MA/CA. The immunofluorescent staining illustrated FBs with normal morphological features. The collagen amount from FBs on the PLA/CA series was 25% higher than that seeded on regular culture‐plates after 7 days incubation. With CA content from 0 to 20%, the collagen amount increased apparently and up to the position of CA20%. Otherwise, with PLA‐g‐MA membranes, the collagen amount showed moderate stimulations. The SEM image presented secreted collagen from FBs on the PLA/CA membrane, indicating the bio‐functional properties of these membranes. The above result analysis, this PLA‐g‐MA/CA composites has good mechanical properties and biocompatible, in the future when use adjusts the formula according to the functionality, may increase the product utility.