Abnormalities in N15 Excretion Rates After Ingestion of Tagged Glycine in Cushing's Syndrome and Following Acth Administration 1

The purpose of this paper is to report studies of excretion rates of isotopic nitrogen, N"1, fol- lowing the ingestion of glycine in which the isotope was chemically incorporated. The studies were carried out on three patients with untreated Cushing's syndrome, and on two of these patients after receiving therapy in the form of X-ray to the pituitary and testosterone propionate respectively. The control studies on healthy volunteers and studies on two of these volunteers after receiving ACTH on three occasions are also reported.