Predictive Value of Mean Platelet Volume and Other CBC Indices for Thrombocytopenia in Pediatric Dengue Fever: A Prospective Observational Study

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Introduction: Dengue fever is a major pediatric health challenge, with thrombocytopenia as a key severity marker. Objectives: To assess the predictive value of mean platelet volume, MPV-to-platelet ratio, and other complete blood count (CBC) indices for severe thrombocytopenia in pediatric dengue. Methods: This prospective observational study enrolled 127 children (1 month-15 years) with confirmed dengue at Hue Central Hospital, Vietnam (January 2023-July 2025). CBC parameters were measured on illness days 3 and 6. Severe thrombocytopenia was defined as platelet count <50 000/µL. Results: < .001; AUC 0.818; sensitivity 75.0%; specificity 88.8%). Elevated MPV, low platelet and lymphocyte counts were also significant. NLR showed moderate value, while PLR and SII were not predictive. Conclusion: MPV/PLT is a simple, early marker for identifying high-risk children with dengue.