Key result
Complete surgical resection of an exceptionally rare alveolar soft part sarcoma in the nasolabial fold of a 31-year-old female resulted in continued remission at 11 months follow-up.
Case Report (n=1)
Complete surgical resection of a rare alveolar soft part sarcoma in the nasolabial fold resulted in remission at 11 months, highlighting the need for clinical suspicion of malignancy in seemingly benign masses.
Supports resection for localized rare sarcoma; extends sparse literature but leaves open long-term outcomes and adjunct needs.
Alveolar soft part sarcoma (ASPS) is a rare malignancy that is morphologically characterized by a distinctive nodular, organoid, or nested growth pattern in which the cells are separated by vascularized septa. The diagnosis is based on a combination of pathologic and immunohistochemical findings and the presence of an ASPSCR1-TFE3 gene fusion revealed by next-generation sequencing. ASPS most commonly occurs as a painless mass in the lower extremity, with likely involvement in the lungs if metastasis is present. Here we report a case of ASPS that exhibited the characteristic ASPSCR1-TFE3 gene fusion along with a reciprocal fusion of TFE3-ASPSCR1, which presented in the nasolabial fold of a 31-year-old female. An intraoral approach was utilized for complete surgical resection of the malignancy, resulting in continued remission after 11 months.
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Palmer et al. (2023) conducted a case report in Alveolar Soft Part Sarcoma (n=1). Complete surgical resection was evaluated on Remission. Complete surgical resection of an exceptionally rare alveolar soft part sarcoma in the nasolabial fold of a 31-year-old female resulted in continued remission at 11 months follow-up.
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