The influence of orally administered 4,4'-(isopropylidenedithio)bis(2,6-di-t-butylphenol) (DH-581) on the development of cholesterol-induced atherosclerosis in rabbits has been investigated. When fed at a level of 0.3% to rabbits who are also being given a diet augmented with 2% cholesterol and 6% corn oil, DH-581 does not affect the course of the cholesterol-induced atherosclerosis. At this dietary level, however, DH-581 did cause reductions in liver triglycerides. When administered at a level of 1% of the atherogenic diet, DH-581 significantly lowers the severity of atheromata in the arch (p)<.05) and thoracic aorta (p<.01) of rabbits.
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Kritchevsky et al. (1971) studied this question.