Different bioadhesive and matrix-forming polymers were evaluated using “in-vitro” tests to identify a potentially convenient “in-vivo” formulation for the sustained delivery of hydrocortisone hemisuccinate to the oral cavity. The selected composition allows an erosion-diffusion mechanism coherent with the low hydrosolubility of the drug and with potential advantages for both the patient and the manufacturer.
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Fábregas et al. (1995) studied this question.
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