Answers are grounded in this paper and cite their sources.
A novel conformationally constrained pyrrolidinyl peptide nucleic acid (PNA) carrying an D-aminopyrrolidine carboxylic acid (D-Apc) spacer was synthesized, and its interactions with complementary oligo- and polynucleotides were studied by UV and CD spectroscopy. The decathymine PNA formed very stable PNA-DNA complexes with poly(dA) and (dA)(10) by a sequence-specific A-T pairing. The interaction with poly(rA) gave the corresponding PNA-RNA complex with much lower stability.
No takes yet. Share an insight, caveat, or question.
Vilaivan et al. (2002) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: