A combined atomic force microscope (AFM) and scanning near-field optical microscope (SNOM) has been constructed to obtain images under liquids. In this combined AFM-SNOM an inverted ac mode configuration is used where the AFM cantilever is driven by exciting acoustic modes of the liquid cell. Optical images of latex spheres on a cantilever have been obtained under perfluorononane, butanol, and water with a lateral resolution of 100 nm. Fluorescence images of latex spheres have been obtained under perfluorononane. The ability to image under liquids opens up a wide range of applications of near field optical microscopy in chemistry and biology.
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Keller et al. (1997) studied this question.
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