Key result
Carotid stenosis of 75-99% and total occlusion caused ipsilateral volume flow reductions of 36% and 51%, respectively, with significant contralateral flow increases via patent collateral vessels.
Why the study?
Does the degree of carotid stenosis and pattern of collateralization affect volume flow rate in patients with extracranial arteriosclerotic lesions?
Observational (n=190)
Does the degree of carotid stenosis and pattern of collateralization affect volume flow rate in patients with extracranial arteriosclerotic lesions?
Answers are grounded in this paper and cite their sources.
Carotid stenosis severity and collateralization patterns demonstrate wide interindividual variability in their hemodynamic impact on volume flow rate.
This study was performed to quantify the volumetric impact of extracranial arteriosclerotic lesions. We investigated patients with different degrees of carotid stenosis as defined by conventional velocity-based duplex criteria and different patterns of collateralization. We studied the volume flow rate (color duplex M-mode device) in 37 patients with symmetrical internal carotid artery (ICA) plaques (<50% stenosis) and compared these data to 43 patients with a unilateral 50-74% stenosis, 75-99% stenosis (n = 73) and occlusion of the ICA (n = 37). A 75-99% stenosis caused an ipsilateral flow reduction of 36% with a wide interindividual variability, and an occlusion of 51%. Collateralization via the ophthalmic artery only caused a nonsignificant ipsilateral volume flow increase, whereas the contralateral volume flow was significantly higher in patients with a patent anterior communicating artery. The increase was more pronounced in patients with an occluded vessel. Our data demonstrate a wide diversity of the hemodynamic impact of carotid stenosis as defined by 'classical' Doppler criteria. Collateral flow reflects a dynamic quantitative process.
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Doberenz et al. (2004) conducted an observational in Carotid stenosis (n=190). Severe carotid stenosis or occlusion vs. Symmetrical internal carotid artery plaques (<50% stenosis) was evaluated on Ipsilateral volume flow reduction. Carotid stenosis of 75-99% and total occlusion caused ipsilateral volume flow reductions of 36% and 51%, respectively, with significant contralateral flow increases via patent collateral vessels.
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