Key result
The evidence underpinning initiation of perioperative beta-blockers in patients with ischemic heart disease undergoing high-risk surgery has been discredited, pointing to an increased risk of death.
Why the study?
Does initiation of perioperative β blockers increase the risk of death in patients with ischaemic heart disease having high risk surgery?
Does initiation of perioperative β blockers increase the risk of death in patients with ischaemic heart disease having high risk surgery?
Answers are grounded in this paper and cite their sources.
Highlights the need for rapid updates to European guidelines to reflect the discredited evidence from the DECREASE trials regarding perioperative beta-blocker initiation.
The trials underpinning initiation of perioperative β blockers in patients with ischaemic heart disease having high risk surgery have largely been discredited, and the remaining evidence points to an increased risk of death. However, changes to the European guidelines have been slow. Graham Cole and Darrel Francis call for improvements to permit guideline experts to perform rapid amendments when required
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Cole et al. (2014) conducted an editorial in Ischaemic heart disease having high risk surgery. Perioperative β blockers was evaluated on Death. The evidence underpinning initiation of perioperative beta-blockers in patients with ischemic heart disease undergoing high-risk surgery has been discredited, pointing to an increased risk of death.
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