Key result
Intradialytic hypertension in CKD-5D patients was associated with a significant 15.32% elevation in endothelin-1 levels during hemodialysis (p=0.013), compared to a 9.77% change without IDH.
Why the study?
To determine the relative change in endothelin-1 during hemodialysis in Stage Five Dialysis-Dependent Chronic Kidney Disease patients with and without intradialytic hypertension.
Does the plasma endothelin-1 (ET-1) level change during hemodialysis in CKD-5D patients with intradialytic hypertension compared to those without?
Cross-Sectional (n=40)
No
Does the plasma endothelin-1 (ET-1) level change during hemodialysis in CKD-5D patients with intradialytic hypertension compared to those without?
Absolute Event Rate: 15.32% vs 9.77%
p-value: p=0.013
Endothelin-1 levels significantly increase during hemodialysis in CKD-5D patients with intradialytic hypertension, suggesting a potential role of ET-1 in its pathogenesis.
Does not support ET-1 targeting in IDH yet; leaves open its mechanistic role for prospective trials.
Objective: To determine the relative change in endothelin-1 (ET-1) during hemodialysis procedure in Stage Five Dialysis-Dependent Chronic Kidney Disease (CKD-5D)patients with and without intradialytic hypertension (IDH).Methods: This was a cross-sectional, observational study involving 40 CKD-5D patients who received two hemodialysis per week for at least three months at the dialysis unit of Dr. Hasan Sadikin Hospital General Bandung, Indonesia during September 2016. Subjects were divided two groups: with IDH (n=20) and without IDH (n=20). Plasma ET-1 level was examined before and after hemodialysis.Results: There was a significant elevation of ET-1 level (mean±SD pg/mL) between pre- and post-dialysis state in patients with IDH (3.33±1.28 vs. 3.84±1.75; relative changes: 15.32%, p=0.013). No change was observed in patients without IDH (3.99±2.30 vs. 4.38±1.81; relative changes: 9.77% p=0.083). The post-dialysis absolute ET-1 level was significantly lower in CKD-5D patients with IDH (3.84±1.75 vs. 4.38±1.81; p=0.024).Conclusion: There was a significant elevation of ET-1 level in CKD-5D patients with IDH during hemodialysis procedure at the dialysis unit of Dr. Hasan Sadikin General Hospital Bandung.
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Gondodiputro et al. (2019) conducted a cross-sectional in Stage Five Dialysis-Dependent Chronic Kidney Disease (CKD-5D) (n=40). Intradialytic hypertension (IDH) vs. Without IDH was evaluated on Relative change in endothelin-1 (ET-1) during hemodialysis procedure (p=0.013). Intradialytic hypertension in CKD-5D patients was associated with a significant 15.32% elevation in endothelin-1 levels during hemodialysis (p=0.013), compared to a 9.77% change without IDH.
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