Effect of the Intravenous Administration of Human Serum Albumin on Renal Function.

The rapid intravenous infusion of 75 g of human serum albumin produced a consistent increase in glomerular filtration rate and renal blood flow. These changes were accompanied by both an increased clearance and a decreased tubular extraction of sodium para-aminohippurate. 2. In 2 patients with the nephrotic syndrome of chronic glomerulonephritis the administration of albumin increased the filtration rate from low to normal levels, and in one of these patients produced a marked diuresis. 3. A possible mechanism for the decreased tubular extraction of PAH accompanying an increased renal blood flow is presented.