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January 1, 2018New Journal of Chemistry

Methotrexate-conjugated mPEG–PCL copolymers: a novel approach for dual triggered drug delivery

Kobra Rostamizadeh Mostafa Manafi Hamed Nosrati Hamidreza Kheiri Manjili Hossein Danafar

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Abstract

A conjugate of the antitumor drug, methotrexate (MTX), with a diblock methoxypoly(ethylene glycol)–poly(caprolactone) (mPEG–PCL) copolymer was synthesized by the reaction of the mPEG–PCL copolymer with MTX in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine.

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Rostamizadeh et al. (2018) studied this question.

synapsesocial.com/papers/6a9b58a7f88c01d2d647e646 https://doi.org/10.1039/c7nj04864e

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Synthesis, characterization, and kinetic release study of methotrexate loaded mPEG–PCL polymersomes for inhibition of MCF-7 breast cancer cell lineOriginal Research · 2018 · 56 citations
2Anticancer Antifolates: Current Status and Future DirectionsClinical Trial · 2003 · 305 citations
3Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritisCross-Sectional Study · 2004 · 337 citations
4Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal conditionOriginal Research · 2018 · 72 citations
5Methotrexate: a detailed review on drug delivery and clinical aspectsClinical Trial · 2012 · 243 citations

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