Key result
In elderly patients with AECOPD and respiratory failure, low molecular weight heparin significantly improved fibrinogen levels, hemorheological markers, and blood gas parameters compared to conventional treatment alone.
Why the study?
Does low molecular weight heparin improve hemorheological markers and blood gases in elderly patients with AECOPD combined with respiratory failure?
RCT (n=60)
Randomly divided
No
Does low molecular weight heparin improve hemorheological markers and blood gases in elderly patients with AECOPD combined with respiratory failure?
Early detection of the prothrombotic state and timely treatment with low molecular weight heparin in elderly patients with AECOPD and respiratory failure improves hemorheology and blood gases without increasing bleeding risk.
Answers are grounded in this paper and cite their sources.
Adjunctive LMWH warrants consideration in elderly AECOPD with respiratory failure; extends RCT evidence for hemorheological and gas-exchange benefits.
The aim of this study was to study the clinical value of prethrombotic state and treatment with low molecular weight heparin (LMWH) in senile patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) combined with respiratory failure. Hemorheological markers (hematocrit, blood viscosity and plasma viscosity), fibrinogen (FIB), D‑dimer and gas analysis were evaluated in 30 senile patients with AECOPD combined with respiratory failure and compared with those in 30 cases without respiratory failure. A total of 30 cases with AECOPD combined with respiratory failure were randomly divided into treatment and control groups. The two groups received conventional treatment. The treatment group also received LMWH injections every 12 h for 6 days and the clinical effect was observed. The levels of FIB, D‑dimer, hematocrit, blood viscosity and plasma viscosity were significantly higher in the patients with AECOPD combined with respiratory failure compared with those in the patients without respiratory failure. The plasma D‑dimer and FIB levels had significantly positive correlations with the partial pressure of CO2 (PaCO2) and negative correlations with the partial pressure of O2 (PaO2) in the patients with AECOPD combined with respiratory failure. The curative effect was improved in the treatment group, compared with that in the control group without side‑effects. However, no significant changes in activated partial thromboplastin time (APTT) and international normalized ratio (INR) were observed between the treatment and control groups. The senile patients with AECOPD combined with respiratory failure suffered from hypercoagulation. Early detection and diagnosis of the prethrombotic state and timely treatment with LMWH may benefit these patients without side‑effects.
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SONG et al. (2013) conducted an RCT in Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with or without respiratory failure (n=60). Low molecular weight heparin (LMWH) vs. Conventional treatment was evaluated on Fibrinogen (FIB) level at day 7 (g/l) (p=<0.05). In elderly patients with AECOPD and respiratory failure, low molecular weight heparin significantly improved fibrinogen levels, hemorheological markers, and blood gas parameters compared to conventional treatment alone.
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