Binding motifs of aminopyrazole derivatives with different peptides in the gas phase are investigated by using mass- and isomer-selective IR/UV spectroscopy. The efficiency of blocking a β-sheet model is determined by analyzing the number and strength of hydrogen bonds (see picture). The investigations yield information on intrinsic molecular properties of beginning aggregation behavior, as might also occur in misfolding diseases.
No takes yet. Share an insight, caveat, or question.
Fricke et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: