Key result
Victims of sudden infant death syndrome demonstrated increased muscularity of the pulmonary circulation, evidenced by muscle extension into arteries and increased medial wall thickness.
Observational (n=15)
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Victims of SIDS show increased muscularity of the pulmonary circulation, suggesting chronic hypoxemia before death and supporting a shift toward investigating chronic abnormalities.
It has recently become apparent that some victims of sudden infant death syndrome (SIDS) are chronically hypoxemic before death. In this study, the structural alterations in the pulmonary circulation of 15 victims of SIDS were examined using precise quantitative morphometric techniques applied to the injected and inflated lung. Increased muscularity of the pulmonary circulation has been demonstrated, as evidenced by the extension of muscle into arteries not usually muscularized during the first year of life, and by an increased thickness of the medial wall in some patients. This confirms the findings of Naeye and further justifies the shift of investigative efforts from the events immediately surrounding death to a search for chronic abnormalities.
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Williams et al. (1979) conducted an observational in Sudden Infant Death Syndrome (SIDS) (n=15). Sudden Infant Death Syndrome was evaluated on Structural alterations in the pulmonary circulation. Victims of sudden infant death syndrome demonstrated increased muscularity of the pulmonary circulation, evidenced by muscle extension into arteries and increased medial wall thickness.
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