Key result
Propofol administration significantly increased the frontal QRS-T angle 15 minutes after colonoscopy compared to basal values (36.2 vs 29.5, P=0.003).
Why the study?
Propofol may affect ventricular repolarization, but no study had investigated its effect on the frontal QRS-T angle.
Does propofol administration increase the frontal QRS-T angle in patients undergoing elective colonoscopy?
Observational (n=56)
Does propofol administration increase the frontal QRS-T angle in patients undergoing elective colonoscopy?
Propofol administration during colonoscopy significantly increases the frontal QRS-T angle, a marker of ventricular depolarization and repolarization difference, suggesting a potential need for ECG monitoring.
Answers are grounded in this paper and cite their sources.
Propofol was associated with increased frontal QRS-T angle during colonoscopy; leaves open arrhythmia risk and requires prospective confirmation before monitoring changes.
WHAT IS KNOWN AND OBJECTIVE: Propofol is a most commonly used anaesthetic drug for conscious sedation in outpatient procedures. Previous studies have shown that propofol may affect ventricular repolarization based on QT and Tp-e intervals. Frontal QRS-T angle is a marker of ventricular depolarization and repolarization difference. However, there is no study investigating the effect of propofol on frontal QRS-T angle. In this study, we aimed to investigate the effect of propofol on frontal QRS-T angle in patients undergoing colonoscopy procedure. METHOD: A total of 56 patients (53.5% females) who underwent colonoscopy procedure were included in this study. All patients underwent 12-lead surface electrocardiograms (ECGs) just before colonoscopy and 15 minutes after colonoscopy. QT interval, QTc interval, Tp-e interval, Tp-e/QT, Tp-e/QTc and frontal QRS-T angle were calculated from 12-lead ECGs. RESULTS AND DISCUSSION: The frontal QRS-T angle was significantly increased 15 minutes after colonoscopy compared to basal value (36.2 ± 24.3 vs. 29.5 ± 23.6, P = .003). In addition, repolarization parameters including QT, QTc and Tp-e intervals were significantly prolonged at 15 minutes after colonoscopy compared to basal value, except Tp-e/QT and Tp-e/QTc. Significant ventricular or supraventricular arrhythmias were not observed in any patient during the procedure. WHAT IS NEW AND CONCLUSION: In this study, we found that propofol administration increased the frontal QRS-T angle in patients undergoing colonoscopy procedure. Given that a prolonged frontal QRS-T angle is associated with ventricular arrhythmias, it may be safer to monitor those patients receiving propofol during colonoscopy procedures.
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Taşcanov et al. (2019) conducted an observational in Elective colonoscopy (n=56). Propofol vs. Basal value (pre-procedure) was evaluated on Frontal QRS-T angle (p=0.003). Propofol administration significantly increased the frontal QRS-T angle 15 minutes after colonoscopy compared to basal values (36.2 vs 29.5, P=0.003).
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