Answers are grounded in this paper and cite their sources.
Going through the channels: Synthetic scaffolds mimicking natural protein functions have been developed that allow water/proton or only water translocation pathways in bilayer membranes (see picture). The ion-exclusion behaviors of the synthetic systems are based on hydrophobic or dimensional steric effects, while hydrodynamic effects appear to be less important.
No takes yet. Share an insight, caveat, or question.
Mihail Bãrboiu (2012) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: