In extension of previous experiments, a study was devised to test the effect on caries activity of adding calcium glycerophosphate to the diet of monkeys. Five experimental and 6 control animals were fed a high carbohydrate diet. Both groups of animals received icing sugar 5 times daily but that fed to the experimental animals contained 1% calcium glycerophosphate. After 30 months it was observed that the control animals had 47 carious lesions and the experimental animals 8 (p < 0.01). All the control animals developed dental caries, whereas 3 of the experimental animals remained caries-free. Higher levels of calcium, and lower concentrations of soluble and insoluble carbohydrate were observed in the plaque of experimental animals than in plaque of the control monkeys. No differences were observed in the protein and total phosphate content. Both the fasting pH values of plaque and those observed 20 min after the application of sucrose were higher in the experimental animals. Slightly higher counts of micro-organisms were found in plaque from the experimental animals.
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Willis H. Bowen (2009) studied this question.