Clinical and Pathological Observations in Fatal Bronchial Asthma

Case Studies1 January 1965Clinical and Pathological Observations in Fatal Bronchial AsthmaReport of a Case Treated with the Immunosuppressive Drug, AzathioprineEDWARD P. COHEN, M.D., THOMAS L. PETTY, M.D., ANDOR SZENTIVANYI, M.D., ROBERT E. PRIEST, M.D.EDWARD P. COHEN, M.D.Search for more papers by this author, THOMAS L. PETTY, M.D.Search for more papers by this author, ANDOR SZENTIVANYI, M.D.Search for more papers by this author, ROBERT E. PRIEST, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-103 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite many recent advances in the understanding of mechanisms of allergic disease, the definitive treatment of asthma remains elusive. The medicinal treatment of asthma consists primarily of a combination of mild sedation, antibiotics, bronchodilating agents, and corticosteroids. Although the basic underlying cause of the disease is unaffected, these measures often are sufficient to evoke symptomatic relief.There is a group of asthmatics who are refractory to the usual measures. These patients require high doses of steroids to control their symptoms, use large amounts of bronchodilatory agents, and are seemingly unimproved by desensitization procedures. Little seasonal incidence to their symptoms can...References1. WALDBOTT GL: Nitrogen mustard in the treatment of bronchial asthma. Ann. Allerg. 10: 428, 1952. MedlineGoogle Scholar2. ROSENWEIGFILLEY DYGF: Postmortem lung studies (mechanical and bronchographic properties). Amer. Rev. Resp. Dis. 88: 6, 1963. MedlineGoogle Scholar3. PETTYMIERCOURTFILLEYMITCHELL TLRGFRS: Airway structure and function of postmortem lungs. Transactions of the 23rd Research Conference on Pulmonary Diseases, VA Armed Forces, 23, 1964 (in press). Google Scholar4. SZENTIVANYIFISCHEL ACW: The amine mediators of the allergic response and the reactivity of their target cells, in Kausale Therapie der Allergischen Krankheiten. Grundprinzipien und Experimentelle Grundlagen, edited by FILIPP, Ferdinand Enke Verlag, Stuttgart (in press). Google Scholar5. PEARLMANSZENTIVANYI DSA: Excessive reactivity of defense mechanisms—allergy, in Biologie Basis of Pediatric Practice, edited by COOK, McGraw-Hill Co., Inc., New York, N. Y. (in press). Google Scholar6. SZENTIVANYIFISCHEL ACW: Effect of bacterial products on the response to the allergic mediators, in Immunological Diseases, edited by SAMTER, Little, Brown and Co., Boston, Mass. (in press). Google Scholar7. FISHELSZENTIVANYITALMAGE CWADW: Sensitization and desensitization of mice to histamine and serotonin by neurohumors. J. Immunol. 89: 8, 1962. MedlineGoogle Scholar8. SZENTIVANYIFISCHELTALMAGE ACWDW: Adrenaline mediation of histamine and serotonin hyperglycemia in normal mice and the absence of adrenaline-induced hyperglycemia in pertussis-sensitized mice. J. Infect. Dis. 113: 86, 1963. CrossrefMedlineGoogle Scholar9. FISHELSZENTIVANYI CWA: The absence of adrenaline-induced hyperglycemia in pertussis-sensitized mice and its relation to histamine and serotonin hypersensitivity. J. Allerg. 34: 439, 1963. CrossrefMedlineGoogle Scholar10. AHLQUIST RP: A study of the adrenotropic receptors. Amer. J. Physiol. 153: 586, 1948. CrossrefMedlineGoogle Scholar11. MORANPERKINS NCME: Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol. J. Pharmacol. Exp. Ther. 124: 223, 1958. MedlineGoogle Scholar12. DRESEL PE: Blockade of some cardiac actions of adrenaline by dichloro-isoproterenol. Canad. J. Biochem. Physiol. 38: 375, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, ColoradoFrom the Departments of Medicine, Microbiology, and Pathology, University of Colorado Medical Center, Denver, Colo.This work was supported in part by grants AI-04152, 2TIHE-5450-04, and AI-04191, U. S. Public Health Service, Bethesda, Md.Dr. Cohen is a Research Career Development Awardee, U. S. Public Health Service.Requests for reprints should be addressed to Edward P. Cohen, M.D., Department of Microbiology, University of Colorado Medical Center, 4200 East Ninth Ave., Denver, Colo. 80220. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySteroid Sparing Therapies in AsthmaMethotrexate RevisitedDifficult-to-Control AsthmaIs Asthma Curable?Acute Reversible Airflow Obstruction (Asthma)Future trends in the management of asthma and chronic obstructive pulmonary diseaseCyclic nucleotides and modulation of effector systems of inflammationSteroid Therapy of Allergic DiseasesAn evaluation of azathioprine in severe chronic asthmaObjective Functional Improvement in Chronic Airway ObstructionAsthmatic HyperresponsivenessMetabolic response to epinephrine in bronchial asthmaComparison of the circulatory and metabolic effects of isoproterenol, epinephrine and methoxamine in normal and asthmatic subjectsCurrent Concepts in the Management of the Patient with Status AsthmaticusThe effect of 6-mercaptopurine on antibody production in atopic individualsClinical effectiveness of 6-mercaptopurine in bronchial asthma 1 January 1965Volume 62, Issue 1Page: 103-109KeywordsAsthmaBradycardiaCareers in researchClinical microbiologyClinical pathologyImmunosuppressivesMedical servicesMicrobiologySedationSteroids Issue Published: 1 January 1965 PDF DownloadLoading ...