IL10 promoter variants in neurocysticercosis: Family-based susceptibility and exploratory genotype-phenotype analyses in Mexican case-parent trios

Given the central role of neuroinflammation in neurocysticercosis (NCC), IL10 promoter variation may influence susceptibility and disease expression. We analyzed rs1800896 (-1082 A > G), rs1800871 (-819C > T), and rs1800872 (-592C > A), together with reconstructed haplotypes/diplotypes, in 92 Mexican case-parent trios. Susceptibility was assessed by exact transmission disequilibrium testing, and exploratory case-only analyses evaluated cerebrospinal fluid (CSF) inflammatory status, parasite burden, location, degenerative stage, and disease-related symptoms. No SNP showed significant transmission distortion after correction for multiple comparisons. The rs1800896 G allele showed borderline over-transmission (38 transmitted vs. 22 non-transmitted; exact p = 0.052), but this was not significant after correction. In exploratory analyses, rs1800896 G dosage and the GCC haplotype showed associations with lower odds of inflammatory CSF before correction for multiple comparisons, whereas the ACC haplotype showed an uncorrected association with the presence of multiple brain parasites. None remained significant after false-discovery rate (FDR) or Bonferroni correction. No symptom-category association remained significant after correction. These data do not support a major role for the analyzed IL10 promoter variants in NCC susceptibility but suggest preliminary inflammatory and radiological signals requiring replication.