Key result
Cardiovascular mortality risk is substantially increased in chronic kidney disease due to uremic toxins, oxidative stress, and inflammation accelerating the atherosclerotic process.
Why the study?
The lack of effective treatment for cardiovascular disease in CKD is a major unmet clinical need, and the precise mechanistic links remain not fully defined.
Answers are grounded in this paper and cite their sources.
Traditional risk factors alone cannot explain the high cardiovascular mortality in CKD, highlighting the need for novel therapies targeting uremic toxins, inflammation, and oxidative stress.
Between 35% and 50% of deaths among patients with chronic kidney disease (CKD) can be attributed to cardiovascular disease.Even after adjusting for traditional cardiovascular risk factors, cardiovascular mortality risk is substantially increased in a linear fashion with decreasing glomerular filtration rate in CKD.Uremic toxins, oxidative stress and inflammation are critical factors found in CKD that can accelerate the atherosclerotic process.Although the precise mechanistic link(s) between CKD and cardiovascular disease are not yet fully defined, this review will discuss the current state of our knowledge.Lack of effective treatment for cardiovascular disease in CKD is a major unmet clinical need that can only be resolved with greater insight into the unique molecular and cellular mechanisms underlying cardiovacular disease pathogenesis in CKD.
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Reiss et al. (2019) conducted a review in Chronic Kidney Disease. Cardiovascular mortality risk is substantially increased in chronic kidney disease due to uremic toxins, oxidative stress, and inflammation accelerating the atherosclerotic process.
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