Key result
Risk assessment scores including ZAHARA, CARPREG II, and modified WHO classification accurately reflected the clinical course and risk of cardiovascular events across three pregnancies in a patient with hypertrophic cardiomyopathy.
Why the study?
Prognostic methods to predict maternal and neonatal outcomes in pregnant women with hypertrophic cardiomyopathy have not yet been established.
Case Report (n=1)
No
ZAHARA, CARPREG II, and modified WHO classification scores during pregnancy are suitable for assessing risk in patients with hypertrophic cardiomyopathy.
The risk of maternal and neonatal mortality in pregnant women with hypertrophic cardiomyopathy (HCM) is considered low, and prognostic methods have not yet been established. In this study, we evaluated several pregnancies in the same patient. In each case, we were able to assess the severity of the mother's cardiac disease and estimate the prognosis. By reviewing the severity of the disease over time and its actual course, we verified the kind of assessment that is important for predicting prognosis. We present the case of a patient who was diagnosed with HCM at 18 years of age and had her first spontaneous pregnancy at 25 years of age. The baby was born at 38 weeks and was healthy, but the mother's HCM worsened after the second trimester of pregnancy, and treatment in the intensive care unit was needed after delivery. After an implantable cardioverter-defibrillator (ICD) implantation, a second pregnancy was established. However, due to repeated arrhythmias requiring ICD activation, a termination of pregnancy was performed due to the risk of worsening maternal heart failure. After radical septal myectomy, a third pregnancy was achieved. In this case, the left ventricular outflow tract stenosis disappeared, the left ventricular outflow tract pressure gradient decreased, and the pregnancy progressed well with no maternal complications. The New York Heart Association (NYHA) and modified World Health Organization (WHO) scores before conceiving were not sufficient to predict pregnancy outcomes. Changes in the disease status during pregnancy were generally consistent with the Zwangerschap bij Aangeboren HARtAfwijkingen (ZAHARA) or pregnancy and congenital heart disease score, Cardiac Disease in Pregnancy Study II (CARPREG II) score, and modified WHO classification ratings, suggesting that they are suitable for assessing risk during pregnancy, and before and after delivery in patients with HCM.
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Shimomoto et al. (2025) conducted a case report in Hypertrophic cardiomyopathy in pregnancy (n=1). Pregnancy was evaluated on Maternal cardiovascular events and pregnancy outcomes. Risk assessment scores including ZAHARA, CARPREG II, and modified WHO classification accurately reflected the clinical course and risk of cardiovascular events across three pregnancies in a patient with hypertrophic cardiomyopathy.
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