Experimental study demonstrates elevated group II phospholipase A2 activity during acute pancreatitis in rats, suggesting an acute-phase response driven by hepatic production.
Editor,—Phospholipase A2(PLA2) is an enzyme that cleaves fatty acids from phospholipids, leading to the generation of inflammatory eicosanoids.1 The group II isoenzyme of phospholipase A2 (PLA2-II) is raised in peripheral blood during various inflammatory states.2 PLA2 is induced in vitro and in vivo by the classic acute phase cytokine interleukin 6.3 ,4 Therefore PLA2-II can be regarded as an acute phase protein. With great interest we read the well designed study of Furue et al ( Gut 1997; 41 :826–31) who could clearly show that most PLA2 activity during sodium deoxycholate induced acute pancreatitis in rats is due to the group II isoenzyme. Furue and colleagues suggested that the liver is the main source of this … Dr Hori.
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Bertsch et al. (1999) studied this question.
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