Key result
Older adults with both handgrip strength weakness and asymmetry had a significantly higher risk of major adverse cardiovascular events compared to those with normal and symmetric strength (HR 5.23).
Why the study?
Handgrip strength weakness and asymmetry have implications for comprehensive geriatric assessment, but their association with cardiovascular outcomes in older outpatients needed investigation.
Does handgrip strength weakness and asymmetry increase the risk of major adverse cardiovascular events in older outpatients?
Cohort (n=364)
No
Does handgrip strength weakness and asymmetry increase the risk of major adverse cardiovascular events in older outpatients?
The combination of handgrip strength weakness and asymmetry is a strong predictor of adverse cardiovascular outcomes in older outpatients, offering complementary prognostic information.
Answers are grounded in this paper and cite their sources.
HGS weakness and asymmetry were associated with cardiovascular outcomes in older outpatients; leaves open incremental prognostic value beyond standard assessment.
AIM: The evaluations of handgrip strength (HGS) weakness and asymmetry have implications for the comprehensive geriatric assessment. The aim of this study was to investigate the association of HGS weakness and asymmetry on cardiovascular outcomes in older outpatients. METHODS: This was a prospective observational cohort study of 364 Geriatrics outpatients aged ≥60 years, in which all participants carried out HGS tests at baseline. Patients with HGS <28 kg for men and <18 kg for women were diagnosed as HGS weakness, and HGS ratio <0.90 or >1.10 were diagnosed as HGS asymmetry. Primary outcomes defined as the major adverse cardiovascular event and composite end-points were assessed during a 21-month median follow-up. RESULTS: Among 364 participants, 155 (42.6%) showed HGS weakness, and 160 (44.0%) showed HGS asymmetry. HGS weakness was associated with major adverse cardiovascular events (HR 2.76, 95% CI 1.22-6.27) and composite end-points (HR 2.84, 95% CI 1.40-5.77). However, no significant correlation between HGS asymmetry and cardiovascular outcomes was observed. Compared with the normal and symmetric HGS group, older adults with HGS weakness and asymmetry together had a higher risk of major adverse cardiovascular events (HR 5.23, 95% CI 1.56-17.54) and composite end-points (HR 4.00, 95% CI 1.56-10.28). CONCLUSIONS: HGS weakness and asymmetry together might increase the risk of cardiovascular outcomes in older outpatients. HGS asymmetry offers complementary information to HGS weakness when making a comprehensive assessment of HGS. Geriatr Gerontol Int 2022; 22: 759-765.
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Lin et al. (2022) conducted a cohort in Cardiovascular outcomes in older outpatients (n=364). Handgrip strength weakness and asymmetry vs. Normal and symmetric handgrip strength was evaluated on Major adverse cardiovascular event (MACE) (HR 5.23, 95% CI 1.56-17.54, p=0.007). Older adults with both handgrip strength weakness and asymmetry had a significantly higher risk of major adverse cardiovascular events compared to those with normal and symmetric strength (HR 5.23).
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