Efficacy of Mitomycin C in Prevention of Adhesions Formation after Functional Endoscopic Sinus Surgery

A prospective randomized clinical trial conducted in Otorhinolaryngology Department, Tishreen University Hospital, Lattakia, Syria, between July 2021 and July 2022. The study included 62 patients underwent bilateral functional endoscopic sinus surgery (Fess) for chronic rhinosinusitis with or without polyps. A cotton pledget soaked with 1 ml of mitomycin C (0.8 mg/ml) was randomly applied in the middle meatus of one nasal cavity (study side) for 5 minutes and a second pledget soaked with 1 ml normal saline was applied in the contralateral side (control side) at the completion of surgery and repeated 3 weeks later.